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5436031 
Journal Article 
Synthesis of some novel 4-substituted coumarins having antibacterial activity (Part-I) 
Mashelkar, UC; Audi, AA 
2005 
Yes 
Journal of the Indian Chemical Society
ISSN: 0019-4522 
82 
3 
254-257 
English 
WOS:000228303600011 
Methyl coumarin-4-methyl acetate on bromination in dioxane or dichloroethane as solvent resulted in sidechain bromination giving cc-bromo derivative. The same reaction when carried out in acetic acid resulted in selective synthesis of 3-bromo derivatives. The a-bromo derivatives on reaction with various area derivatives give novel nitrogen heterocycles (imidazolones) substituted at 4-position of coumarin ring. The a-bromo derivatives when reacted with various 1,2-diamino compounds yielded fused 2-pyrazinones attached at 4-position of coumarin ring. Considering the potential biological activities of other 4-substituted coumarins and biological importance of imidazoles, pyrazines, triazines and oxazines in drug synthesis, the new heterocycles were examined for antibacterial properties and have shown positive results.< 
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