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Citation
Tags
HERO ID
5443919
Reference Type
Journal Article
Subtype
Review
Title
Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models
Author(s)
Hang, B; Wang, P; Zhao, Y; Sarker, A; Chenna, A; Xia, Y; Snijders, AM; Mao, JH
Year
2017
Is Peer Reviewed?
Yes
Journal
International Journal of Molecular Sciences
ISSN:
1422-0067
EISSN:
14220067
Volume
18
Issue
5
Language
English
PMID
28452951
DOI
10.3390/ijms18050932
Abstract
The newly identified smoke hazard, thirdhand smoke (THS), has gained public attention in recent years but its health impact and biological effects are largely unknown. THS may be defined by "the four Rs": tobacco chemicals that remain, react, re-emit, and/or are resuspended long after active smoking has ceased. This review summarizes recent research progress in the effects of THS on genotoxicity, metabolism and early life development using cellular and animal models. We first reported that THS generated in laboratory systems caused significant DNA damage in human cell lines. Our finding that THS significantly induces oxidative base lesions has been confirmed in skin wounds of mice models exposed to THS. THS also induced metabolomic changes in human reproductive cell lines. Furthermore, we demonstrated that early exposure to THS not only negatively impacts body weight in both male and female mice, but also induces persistent changes to immunological parameters in peripheral blood in these mice. These results indicate that THS is genotoxic at realistic experimental doses and that there may be a window of susceptibility for some forms of cellular damage induced by THS.
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