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5445391 
Journal Article 
GLC Determination of Plasma Concentrations of γ-OxO Metabolite of Phenylbutazone 
Midha, KK; Mcgilveray, IJ; Cooper, JK 
1978 
Yes 
Journal of Pharmaceutical Sciences
ISSN: 0022-3549
EISSN: 1520-6017 
67 
2 
279-281 
English 
621659 
A quantitative method for the γ-OxO metabolite of phenylbutazone from plasma is described. The procedure involved an ethylene dichloride extraction of acidified plasma to which an internal standard, acenocoumarol, had been added. The extracted γ-OxO metabolite and the internal standard were methylated and analyzed by GLC. Determination of 0.25μg of γ-OxO metabolite/ml with a relative standard deviation of 6.5% was accomplished. 
Phenylbutazone γ-OxO metabolite—GLC analysis in plasma; Metabolites—γ-OxO derivative of phenylbutazone; γ-OxO metabolite of phenylbutazone—GLC analysis in plasma; GLC—analysis; Antirheumatic agents—phenylbutazone