Health & Environmental Research Online (HERO)


Print Feedback Export to File
5452464 
Journal Article 
Debenzylation of Functionalized 4-and 5-Substituted 1,2,3-Triazoles 
Farooq, T; Sydnes, LK; Tornroos, KW; Haug, BE 
2012 
1 
Synthesis
ISSN: 0039-7881
EISSN: 1437-210X 
GEORG THIEME VERLAG KG 
STUTTGART 
44 
13 
2070-2078 
English 
WOS:000306112600020 
A range of 4- and 5-substituted N-benzyl-1,2,3-triazoles have been submitted to debenzylation using Pd/C and hydrogen in the presence of 1,1,2-trichloroethane. Triazoles with oxygen-containing substituents are efficiently debenzylated under these conditions. Triazoles with a phenyl or benzyl substituent on C4 or C5 are not debenzylated, whereas a pentyl-substituted derivative was readily debenzylated. © Georg Thieme Verlag Stuttgart • New York. 
hydrogenolysis; triazoles; alkynes; debenzylation; dehydrochlorination