Should sodium calcium edetate remain the chelating agent of choice in the management of lead poisoning? | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

545773

Reference Type

Journal Article

Title

Should sodium calcium edetate remain the chelating agent of choice in the management of lead poisoning?

Author(s)

Bradberry, SM

Year

2006

Is Peer Reviewed?

Journal

Clinical Toxicology
ISSN: 1556-3650
EISSN: 1556-9519

Volume

Issue

Language

English

Abstract

Worldwide sodium calcium edetate (edetate calcium disodium) has been the antidote of choice in the treatment of lead poisoning since it was introduced in 1954. However, the dimercaprol derivative, succimer (DMSA [dimercaptosuccinic acid]), which was first used as an antidote for heavy metal poisoning in 1965 in China, has been considered increasingly as a potential alternative. Are there sufficient clinical data to attribute antidotal superiority to either agent in the treatment of inorganic lead poisoning? In considering all availab1e data, it must be recognized that because of their different molecular weights when both agents are administered in equal mass doses, the molar amount of DMSA is approximately double that of sodium calcium edetate. Sodium calcium edetate versus DMSA.

Keywords

Article Subject Terms: Antidotes; Calcium; Chelating agents; Heavy; metals; Lead; Molars; Molecular weight; Poisoning; Sodium; Teeth; succimer; X 24360 Metals