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5474162 
Journal Article 
Effects of gamma-tocopherol supplementation on thrombotic risk factors 
Singh, I; Turner, AH; Sinclair, AJ; Li, D; Hawley, JA 
2007 
Yes 
Asia Pacific Journal of Clinical Nutrition
ISSN: 0964-7058
EISSN: 1440-6047 
Asia Pac J Clin Nutr. 2007; 16(3):422-8. [Asia Pacific journal of clinical nutrition] 
English 
OBJECTIVE: The antioxidant activity of vitamin E is derived primarily from alpha-tocopherol (alpha-T) and gamma-tocopherol (gamma-T). Results of epidemiological studies have demonstrated an inverse relationship between vitamin E intake and coronary disease. However, the results of clinical trials using alpha-T are equivocal. We determined the effect of 5 weeks of 100 mg/d or 200 mg/d gamma-T supplementation on thrombotic markers such as platelet reactivity, lipid profile and the inflammation marker C-reactive protein (CRP). METHODS AND RESULTS: Fourteen healthy subjects consumed 100 mg/day while 13 consumed 200 mg/d of gamma-T and 12 received placebo (soybean capsules with less than 5 mg/d gamma-T) in a double-blinded parallel study design. Fasting pre and post dose blood samples were analysed. Blood gamma-T concentrations increased significantly (p < 0.05) relative to dose during the intervention period. Both groups receiving active ingredients showed significantly lower platelet activation after supplementation (p < 0.05). Subjects consuming 100 mg/d gamma-T had significantly decreased LDL cholesterol, platelet aggregation and mean platelet volume (MPV) (p < 0.05). Little effect of gamma-T was observed on other parameters. CONCLUSIONS: These data suggest that gamma-T supplementation may have a permissive role in decreasing the risk of thrombotic events by improving lipid profile and reducing platelet activity. 
Adult; Antioxidants/administration & dosage/metabolism; Blood Platelets/metabolism; C-Reactive Protein/metabolism; Cholesterol, LDL/blood; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Fasting; Lipids/blood; Platelet Activation/drug effects; Platelet Aggregation/drug effects; Risk Factors; Thrombosis/blood/prevention & control; gamma-Tocopherol/administration & dosage/blood; 8EF1Z1238F; 9007-41-4