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5474166 
Journal Article 
Methyltrienolone, a specific ligand for cellular androgen receptors 
Bonne, C; Raynaud, JP 
1975 
1 
Steroids
ISSN: 0039-128X
EISSN: 1878-5867 
26 
2 
227-232 
Methyltrienolone (R 1881), 17β-hydroxy-17α-methyl-estra-4,9,11-trien-3-one, a very active androgen, binds specifically to rat prostate cytosol with a higher affinity than androstanolone. Unlike the physiological hormone, however, it is not bound by human sex steroid plasma binding protein, SBP. This specific ligand is thus a useful tool for the detection of elusive androgen receptors and for their study, for instance, in human tumors where interference from plasma contamination has to be circumvented.