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HERO ID
5499624
Reference Type
Journal Article
Subtype
Review
Title
Effects of bisphenol A and its analogs on reproductive health: A mini review
Author(s)
Siracusa, JS; Yin, L; Measel, E; Liang, S; Yu, X
Year
2018
Is Peer Reviewed?
1
Journal
Reproductive Toxicology
ISSN:
0890-6238
EISSN:
1873-1708
Volume
79
Page Numbers
96-123
Language
English
PMID
29925041
DOI
10.1016/j.reprotox.2018.06.005
Web of Science Id
WOS:000439741700014
URL
https://search.proquest.com/docview/2057867093?accountid=171501
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Abstract
Known endocrine disruptor bisphenol A (BPA) has been shown to be a reproductive toxicant in animal models. Its structural analogs: bisphenol S (BPS), bisphenol F (BPF), bisphenol AF (BPAF), and tetrabromobisphenol A (TBBPA) are increasingly being used in consumer products. However, these analogs may exert similar adverse effects on the reproductive system, and their toxicological data are still limited. This mini-review examined studies on both BPA and BPA analog exposure and reproductive toxicity. It outlines the current state of knowledge on human exposure, toxicokinetics, endocrine activities, and reproductive toxicities of BPA and its analogs. BPA analogs showed similar endocrine potencies when compared to BPA, and emerging data suggest they may pose threats as reproductive hazards in animal models. While evidence based on epidemiological studies is still weak, we have utilized current studies to highlight knowledge gaps and research needs for future risk assessments.
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