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552103 
Journal Article 
Phase contact dans la réponse hémostatique et vasculaire vers un système intégré 
Berger, A; Matei, C; Lallemant, P; Guiot, P; Bischoff, N; Delabranche, X 
2006 
27 
Supplement 1 
S31-S34 
Contact system was thought to be an accessory pathway for thrombin generation. It appears that this system participate to fibrinolysis, vascular tone and capillary permeability regulation. These actions are mediated by FXII and bradykinin generated from high molecular weight kininogen. C1-inhibitor is the main regulatory protein. During cardiopulmonary bypass, activation of contact system occurs with secondary fibrinolysis, capillary leak syndrome and vasopl6gie. CI-inhibitor consumption leads to acquired deficit and therapeutic use may be of interest. 
Phase contact; C I-inhibiteur; Circulation extracorporelle; Fuite capillaire; Contact system; CI-inhibitor; Cardiopulmonary bypass; Capillary leak syndrome