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553927 
Journal Article 
The acute effects of intranasal oxytocin administration on endocrine and sexual function in males 
Burri, A; Heinrichs, M; Schedlowski, M; Kruger, THC 
2008 
1 
Psychoneuroendocrinology
ISSN: 0306-4530 
33 
5 
591-600 
English 
18375074 
WOS:000256782200005 
Summary The role of the neuropeptide oxytocin (OT) ranges from the modulation of neuroendocrine physiological effects to the establishment of complex social and bonding behaviours. Experimental studies in animals, as well as case reports in humans, suggest that OT affects different aspects of sexual behaviour and has predominantly facilitating properties for sexual appetence and performance. Using a previously established experimental paradigm of sexual arousal and masturbation-induced orgasm, this study investigated the acute effects of intranasal OT application (24 I.U.) on endocrine parameters and measures of sexual appetence and function in healthy men (n=10). In a double-blind, placebo-controlled, balanced cross-over design, sexual arousal, and orgasm were induced by an erotic film and masturbation. In addition to the continuous recording of endocrine (OT, cortisol, prolactin, epinephrine, norepinephrine) and cardiovascular data (heart rate), parameters of appetetive, consummatory, and refractory sexual behaviour were assessed using the acute sexual experience scale (ASES). 
Oxytocin; Intranasal; Epinephrine; Norepinephrine; Sexual function; Sexual arousal