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555271 
Journal Article 
Chronobiology, excessive daytime sleepiness and depression: Is there a link? 
Chellappa, SL; Schroder, C; Cajochen, C 
2009 
1 
Sleep Medicine
ISSN: 1389-9457 
10 
5 
505-514 
The complaint of excessive daytime sleepiness (EDS), commonly encountered in clinical practice, may arise from a variety of psychiatric disorders, most importantly depression. Even though EDS frequently leads depressed patients to seek medical assistance, it is commonly under-evaluated and under-diagnosed. Therefore, a comprehensive understanding and management of EDS is essential in the clinical assessment of depression. Within a theoretical framework, a chronobiological approach may shed new light on the complex interaction of EDS and depression. In this review, studies on EDS and depression are summarized and discussed within the context of circadian and sleep regulatory mechanisms. Furthermore, potential chronobiological therapeutic strategies are proposed to address some of the unmet needs in the treatment of EDS and depression. 
Daytime sleepiness; Sleep disorders; Depressive disorders; Light therapy; Sleep deprivation; Circadian rhythm