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5553422 
Journal Article 
4-Phenylcyclohexene: 2-Week inhalation toxicity and neurotoxicity studies in Swiss-Webster mice 
Beekman, MJ; Maurissen, JP; Johnson, KA 
1996 
Yes 
Food and Chemical Toxicology
ISSN: 0278-6915
EISSN: 1873-6351 
Elsevier Ltd 
34 
9 
873-881 
English 
8972880 
WOS:A1996VY05300004 
BIOSIS COPYRIGHT: BIOL ABS. 4-Phenylcyclohexene (4-PCH) is a by-product formed during the polymerization of styrene-butadiene latex used in carpet backing. Limited reports suggest that exposure to very low levels of 4-PCH or other emission products following new carpet installation may result in health complaints. Significantly, it has been claimed that Swiss-Webster mice held in neck restraints and exposed head-only to approximately 0.4 ppm 4-PCH for a few hours suffered severe toxicity including death. A 2-wk inhalation and neurotoxicity study was therefore conducted in Swiss-Webster mice using standard methods of toxicity testing. Groups of 40 mice were exposed to 0, 7, 18 or 71 ppm (near-saturated atmosphere) 4-PCH vapour, 6 hr/day for 9 consecutive days. Data were collected on a wide variety of clinical, neurological and histopathological parameters including extensive neurohistopathology. All animals survived the exposures, and there were no treatment-related effects. Because of the occurren 
Cyclohexanes; 4-phenylcyclohexene; CW63R89OW9; Index Medicus; Floors and Floorcoverings; Spinal Cord -- pathology; Animals; Body Weight; Brain -- pathology; Vacuoles -- pathology; Administration, Inhalation; Motor Activity -- drug effects; Organ Size -- drug effects; Nervous System Diseases -- chemically induced; Cyclohexanes -- administration & dosage; Cyclohexanes -- toxicity; Nervous System Diseases -- pathology