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5573556 
Journal Article 
Amphiphilic derivatives of sodium alginate and hyaluronate: synthesis and physico-chemical properties of aqueous dilute solutions 
Pelletier, S; Hubert, P; Lapicque, F; Payan, E; Dellacherie, E 
2000 
Yes 
Carbohydrate Polymers
ISSN: 0144-8617
EISSN: 1879-1344 
43 
4 
343-349 
WOS:000089301700006 
This paper reports on the synthesis and the physico-chemical characterisation of various amphiphilic derivatives of two natural polysaccharides, sodium alginate and sodium hyaluronate, in which a rather small proportion of the carboxylic groups (≤10% mol) was esterified by long alkyl chains (C12H25 or C18H37). The derivatives thus prepared were characterised by gas chromatography, 1H and 13C n.m.r. spectroscopy and size exclusion chromatography coupled to a multi-angle laser light scattering detection. The tendency of these water-soluble compounds to hydrophobic association in aqueous solutions was evidenced firstly in dilute regime using capillary viscometry as well as fluorescence spectroscopy in the presence of a molecular probe, 1,1-dicyano-(4′-N,N-dimethylaminophenyl)-1,3-butadiene. 
Associative polysaccharides; Hyaluronate; Alginate; Fluorescence; Viscometry