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557724 
Journal Article 
Severe T-cell depletion from the PALS leads to altered spleen composition in common marmosets with experimental autoimmune encephalomyelitis (EAE) 
De Vos, AF; van Riel, DAJ; van Meurs, M; Brok, HPM; Boon, L; Hintzen, RQ; Claassen, E; t Hart, BA; Laman, JD 
2005 
Yes 
Journal of Neuroimmunology
ISSN: 0165-5728
EISSN: 1872-8421 
161 
1-2 
29-39 
Recent data suggest that the spleen is a crucial component of the immune system in the development of experimental autoimmune encephalomyelitis (EAE) in marmoset monkeys. Using immunohistochemistry, we investigated changes in the distribution of leukocytes in the spleen associated with clinical symptoms of EAE. Animals without EAE displayed well-developed T- and B-cell areas, germinal centers and red pulp. In contrast, a marked depletion of periarteriolar T cells with preservation of other elements was found in animals with clinical EAE. These findings suggest that immune responses within the spleen are impaired during a paralysing inflammatory process in the central nervous system. 
Autoimmunity; Lymphoid organ; Lymphopenia; Multiple sclerosis; Myelin oligodendrocyte glycoprotein; Non-human primate