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HERO ID
559238
Reference Type
Journal Article
Title
Tetrazole and ester substituted tetrahydoquinoxalines as potent cholesteryl ester transfer protein inhibitors
Author(s)
Eary, CT; Jones, ZS; Groneberg, RD; Burgess, LE; Mareska, DA; Drew, MD; Blake, JF; Laird, ER; Balachari, D; O'Sullivan, M; Allen, A; Marsh, V
Year
2007
Is Peer Reviewed?
Yes
Journal
Bioorganic & Medicinal Chemistry Letters
ISSN:
0960-894X
EISSN:
1464-3405
Volume
17
Issue
9
Page Numbers
2608-2613
DOI
10.1016/j.bmcl.2007.01.112
Abstract
Cholesteryl ester transfer protein is a plasma glycoprotein that transfers cholesterol ester between lipoprotein particles. Inhibition of this protein, in vitro and in vivo, produces an increase in plasma high density lipoprotein cholesterol (HDL-C). This communication will describe the SAR and synthesis of a series of substituted tetrahydroquinoxaline CETP inhibitors from early [mu] lead to advanced enantiomerically pure analogs.
Keywords
Cholesteryl ester transfer protein; CETP; HDL; Tetrahydoquinoxalines; Cholesterol
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