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5630267 
Journal Article 
[The impact of endocrine disruptors on membrane fatty acid composition of carp organs] 
Zhang, X; Jing, B; Yuan, X; Guo, D 
2014 
Yes 
Huanjing Huaxue / Environmental Chemistry
ISSN: 0254-6108 
33 
5 
748-752 
Chinese 
Three kinds of endocrine disruptors estradiol, bisphenol A, dibutyl phthalate and testosterone were exposed at carp, and the effect of them on the content and composition of fatty acid in cell membrane and adenylate cyclase activity in cell of carp hepatopancreas, gonads and brain had been studied. The result showed that to three organs of carp, the exposure of endocrine disruptors can make the contents of saturated fatty acid increased; unsaturated fatty acid decreased in cell membranes, and make the number of double bonds lowered in unsaturated fatty acid. As a result, the structure and function of cell membranes in organs were possibly affected. In hepatopancreas and gonads, the effect of testosterone exposure was consistent with the effect of estradiol exposure in saturated fatty acid content, but is antagonistic with it in the content of unsaturated fatty acid arachidonic acid and docosahexaenoic acid. The result of enzyme activity assay showed that the mechanism of fatty acid metabolism change for exposure, thereby affecting the structure and function of cell membrane, may be related to the activity altered of adenylate cyclase in cell membrane. 
Aqualine Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Environment Abstracts; endocrine disruptors; cell membrane; fatty acids; adenylate cyclase; Membranes; Testing Procedures; Geochemistry; Arachidonic acid; Freshwater; Enzymatic activity; Freshwater fish; Water Pollution Effects; Cell membranes; Exposure; Metabolism; Environmental impact; Phthalates; Sex hormones; Bisphenol A; Endocrinology; ENA 02:Toxicology & Environmental Safety