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Citation
Tags
HERO ID
566362
Reference Type
Journal Article
Title
Activation of ERK in the locus coeruleus following acute noxious stimulation
Author(s)
Imbe, H; Okamoto, K; Donishi, T; Kawai, S; Enoki, K; Senba, E; Kimura, A
Year
2009
Is Peer Reviewed?
Yes
Journal
Brain Research
ISSN:
0006-8993
EISSN:
1872-6240
Volume
1263
Page Numbers
50-57
Language
English
PMID
19368817
DOI
10.1016/j.brainres.2009.01.052
Web of Science Id
WOS:000265039800006
URL
http://
://WOS:000265039800006
Exit
Abstract
In the present study, the activation of extracellular signal-regulated kinase (ERK) in the locus coeruleus (LC) following injection of formalin or complete Freund's adjuvant (CFA) into the rat hindpaw was examined in order to clarify the mechanisms underlying the dynamic changes in the descending pain modulatory system after acute noxious stimulation or chronic inflammation. In naive rats there were few phospho-extracellular signal-regulated kinase-immunoreactive (p-ERK-IR) neurons in the LC. Formalin-, CFA- and saline-injections induced an increase in p-ERK-IR in the LC. The number of p-ERK-IR neurons in the LC in the formalin group was significantly higher than those in all other groups from 5 min to 1 h after the injection (p < 0.05). CFA injection induced only a transient significant increase in the number of p-ERK-IR neurons and there was no significant difference in the number of p-ERK-IR neurons between the CFA and saline groups. At 5 min after formalin injection, almost all p-ERK-IR neurons in the LC were tyrosine hydroxylase (TH) -positive. These findings suggest that activation of ERK in the LC is induced by acute noxious stimulation, such as formalin injection, but not by CFA-induced chronic inflammation. The activation of ERK in the LC may be involved in the plasticity of the descending pain modulatory systems following acute noxious stimulation.
Keywords
Descending system; MAPK; Formalin; Inflammation
Tags
IRIS
•
Formaldehyde [archived]
Nervous system effects
Found
Database search results
Web of Science
Screened
Title/abstract
Non-relevant exposure paradigm
Retroactive RIS import
Pre2013
Merged Litsearch Results 100912
Merged LitSearch Results ToxNet 101012
Merged LitSearch Additions 86 Reviews SCREEN
Web of Science Search 100412
2013
HCHON tox Ref Identification 022713
•
IRIS Formaldehyde (Inhalation) [Final 2024]
Literature Indexing
WoS
Literature Identification
Nervous System Effects
Excluded
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