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568734 
Journal Article 
DJ-1, a novel regulator of the tumor suppressor PTEN 
Kim, RH; Peters, M; Jang, Y; Shi, W; Pintilie, M; Fletcher, GC; DeLuca, C; Liepa, J; Zhou, L; Snow, B; Binari, RC; Manoukian, AS; Bray, MR; Liu, FF; Tsao, MS; Mak, TW 
2005 
1 
Cancer Cell
ISSN: 1535-6108
EISSN: 1878-3686 
7 
3 
263-273 
Summary The phosphatidylinositol 3' kinase (PI3'K) pathway, which regulates cell survival, is antagonized by the PTEN tumor suppressor. The regulation of PTEN is unclear. A genetic screen of Drosophila gain-of-function mutants identified DJ-1 as a suppressor of PTEN function. In mammalian cells, DJ-1 underexpression results in decreased phosphorylation of PKB/Akt, while DJ-1 overexpression leads to hyperphosphorylation of PKB/Akt and increased cell survival. In primary breast cancer samples, DJ-1 expression correlates negatively with PTEN immunoreactivity and positively with PKB/Akt hyperphosphorylation. In 19/23 primary non-small cell lung carcinoma samples, DJ-1 expression was increased compared to paired nonneoplastic lung tissue, and correlated positively with relapse incidence. DJ-1 is thus a key negative regulator of PTEN that may be a useful prognostic marker for cancer.