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5705557 
Journal Article 
Uptake and fate of di-2-ethylhexyl phthalate in aqutic organisms and in a model ecosystem 
Metcalf, RL; Booth, GM; Schuth, CK; Hansen, DJ; Lu, PY 
1973 
Yes 
Environmental Health Perspectives
ISSN: 0091-6765
EISSN: 1552-9924 
4 
27-34 
English 
4721303 
The experiments reported demonstrate that di 2 ethylhexyl phthalate (DEHP) is a microchemical environmental pollutant which is rapidly biomagnified by a variety of plants and animals in an aquatic system. DEHP is biodegraded very slowly in algae, Daphnia, mosquito larvae, snails, and clams and more rapidly in fish by hydrolysis at the ester bonds to form monoethylhexyl phthalate, phthalic acid, phthalic anhydride, and a variety of polar metabolites and conjugates. However, DEHP closely resembles DDT in rate of uptake and storage, and it obviously partitions strongly in the lipids of plants and animals and ,is concentrated through food chains. The biomagnification of DEHP together with its teratogenic properties and its enormous rate of production and ubiquitous use indicate the need for much further study of its environmental distribution and fate. Present data suggest the need for restrictions on the use and waste disposal of DEHP. 
phthalic acid bis(2 ethylhexyl) ester; phthalic acid bis(2 ethylhexyl) ester c 14; unclassified drug; arthropod; article; autoradiography; drug metabolism; drug storage; ecology; environmental health; fish; invertebrate; model; pharmacokinetics; theoretical study