Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
5785819
Reference Type
Journal Article
Subtype
Review
Title
Use of nonobese diabetic mice to understand human type 1 diabetes
Author(s)
Thayer, TC; Wilson, SB; Mathews, CE
Year
2010
Is Peer Reviewed?
Yes
Journal
Endocrinology & Metabolism Clinics of North America
ISSN:
0889-8529
Volume
39
Issue
3
Page Numbers
541-561
Language
English
PMID
20723819
DOI
10.1016/j.ecl.2010.05.001
Web of Science Id
WOS:000282146100007
Abstract
In 1922, Leonard Thompson received the first injections of insulin prepared from the pancreas of canine test subjects. From pancreatectomized dogs to the more recent development of animal models that spontaneously develop autoimmune syndromes, animal models have played a meaningful role in furthering diabetes research. Of these animals, the nonobese diabetic (NOD) mouse is the most widely used for research in type 1 diabetes (T1D) because the NOD shares several genetic and immunologic traits with the human form of the disease. In this article, the authors discuss the similarities and differences in NOD and human T1D and the potential role of NOD mice in future preclinical studies, aiming to provide a better understanding of the genetic and immune defects that lead to T1D.
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity