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HERO ID
5787120
Reference Type
Journal Article
Title
Association between vitamin D receptor gene polymorphisms and type 1 diabetes mellitus in Iranian population
Author(s)
Mohammadnejad, Z; Ghanbari, M; Ganjali, R; Afshari, JT; Heydarpour, M; Taghavi, SM; Fatemi, S; Rafatpanah, H
Year
2012
Is Peer Reviewed?
1
Journal
Molecular Biology Reports
ISSN:
0301-4851
EISSN:
1573-4978
Volume
39
Issue
2
Page Numbers
831-837
Language
English
PMID
21584699
DOI
10.1007/s11033-011-0805-3
Web of Science Id
WOS:000298751300006
Abstract
Type 1 diabetes mellitus (T1DM) is one of the T-cell mediated autoimmune diseases and vitamin D suppresses activation of T-cell and has immunomodulatory effects. In this study the association between four vitamin D receptor (VDR) gene polymorphisms, at positions FokI, BsmI, ApaI and TaqI, and susceptibility to T1DM was investigated. We assessed 87 Iranian patients with T1DM and one hundred healthy controls with no history of diabetes or other autoimmune diseases. Our results demonstrated that genotypes frequency of the TaqI VDR polymorphism differed significantly between T1DM patients and controls, TT genotype and T allele was more frequent in healthy controls compared with TIDM patients (P = 0.003; OR = 0.51, 95% CI = 0.31-0.84). Therefore, allele t is the risk-allele for developing TIDM in this study. No significant association was observed between others VDR SNPs and disease susceptibility. In conclusion, our case-control study indicated that the VDR TaqI polymorphism is associated with TIDM in Iranian population.
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