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HERO ID
5787726
Reference Type
Journal Article
Title
Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression
Author(s)
Lindegaard, ML; Damm, P; Mathiesen, ER; Nielsen, LB
Year
2006
Is Peer Reviewed?
Yes
Journal
Journal of Lipid Research
ISSN:
0022-2275
EISSN:
1539-7262
Volume
47
Issue
11
Page Numbers
2581-2588
Language
English
PMID
16940551
DOI
10.1194/jlr.M600236-JLR200
Web of Science Id
WOS:000241667300023
Abstract
Maternal diabetes can cause fetal macrosomia and increased risk of obesity, diabetes, and cardiovascular disease in adulthood of the offspring. Although increased transplacental lipid transport could be involved, the impact of maternal type 1 diabetes on molecular mechanisms for lipid transport in placenta is largely unknown. To examine whether maternal type 1 diabetes affects placental lipid metabolism, we measured lipids and mRNA expression of lipase-encoding genes in placentas from women with type 1 diabetes (n = 27) and a control group (n = 21). The placental triglyceride (TG) concentration and mRNA expression of endothelial lipase (EL) and hormone-sensitive lipase (HSL) were increased in placentas from women with diabetes. The differences were more pronounced in women with diabetes and suboptimal metabolic control than in women with diabetes and good metabolic control. Placental mRNA expression of lipoprotein lipase and lysosomal lipase were similar in women with diabetes and the control group. Immunohistochemistry showed EL protein in syncytiotrophoblasts facing the maternal blood and endothelial cells facing the fetal blood in placentas from both normal women and women with diabetes. These results suggest that maternal type 1 diabetes is associated with TG accumulation and increased EL and HSL gene expression in placenta and that optimal metabolic control reduces these effects.
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