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HERO ID
584878
Reference Type
Journal Article
Title
CD8 T cell dysfunction during chronic viral infection
Author(s)
Shin, H; Wherry, EJ
Year
2007
Is Peer Reviewed?
Yes
Journal
Current Opinion in Immunology
ISSN:
0952-7915
Volume
19
Issue
4
Page Numbers
408-415
DOI
10.1016/j.coi.2007.06.004
Abstract
Clearance of primary infection often leads to the development of highly functional memory T cells capable of rapid and long-lasting protective immunity. By contrast, chronic infections can result in T cell dysfunction and poor pathogen control. In this review, we will discuss recent work that highlights two main types of T cell dysfunction during chronic infection: exhaustion of effector functions and altered memory T cell development.
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