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584878 
Journal Article 
CD8 T cell dysfunction during chronic viral infection 
Shin, H; Wherry, EJ 
2007 
Yes 
Current Opinion in Immunology
ISSN: 0952-7915 
19 
4 
408-415 
Clearance of primary infection often leads to the development of highly functional memory T cells capable of rapid and long-lasting protective immunity. By contrast, chronic infections can result in T cell dysfunction and poor pathogen control. In this review, we will discuss recent work that highlights two main types of T cell dysfunction during chronic infection: exhaustion of effector functions and altered memory T cell development.