New cationic lipids for gene transfer with high efficiency and low toxicity: T-shape cholesterol ester derivatives | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

5916860

Reference Type

Journal Article

Title

New cationic lipids for gene transfer with high efficiency and low toxicity: T-shape cholesterol ester derivatives

Author(s)

Lee, Y; Koo, H; Lim, YB; Lee, Y; Mo, H; Park, JS

Year

2004

Is Peer Reviewed?

Yes

Journal

Bioorganic & Medicinal Chemistry Letters
ISSN: 0960-894X
EISSN: 1464-3405

Volume

Issue

Page Numbers

2637-2641

Language

English

PMID

15109668

DOI

10.1016/j.bmcl.2004.02.061

Abstract

New degradable cationic ester lipids with 'T-shape' configurations were synthesized and tested for gene delivery carrier. Their transfection efficiency and toxicity were compared with commercially available cationic lipids, DOTMA, DOSPA, and DC-Chol. They showed efficient transfection activity and almost no toxicity on mammalian cell lines. Their ester bond degradation was monitored by (1)H NMR.