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HERO ID
5918647
Reference Type
Journal Article
Subtype
Review
Title
Air pollution and cardiovascular disease: JACC State-of-the-Art Review
Author(s)
Rajagopalan, S; Al-Kindi, SG; Brook, RD
Year
2018
Is Peer Reviewed?
Yes
Journal
Journal of the American College of Cardiology
ISSN:
0735-1097
EISSN:
1558-3597
Volume
72
Issue
17
Page Numbers
2054-2070
Language
English
PMID
30336830
DOI
10.1016/j.jacc.2018.07.099
Web of Science Id
WOS:000447378100010
Abstract
Fine particulate matter <2.5 μm (PM2.5) air pollution is the most important environmental risk factor contributing to global cardiovascular (CV) mortality and disability. Short-term elevations in PM2.5 increase the relative risk of acute CV events by 1% to 3% within a few days. Longer-term exposures over several years increase this risk by a larger magnitude (∼10%), which is partially attributable to the development of cardiometabolic conditions (e.g., hypertension and diabetes mellitus). As such, ambient PM2.5 poses a major threat to global public health. In this review, the authors provide an overview of air pollution and health, including assessment of exposure, impact on CV outcomes, mechanistic underpinnings, and impact of air pollution reduction strategies to mitigate CV risk. The review concludes with future challenges, including the inextricable link between air pollution and climate change, and calls for large-scale trials to allow the promulgation of formal evidence-based recommendations to lower air pollution-induced health risks.
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