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5920416 
Journal Article 
The toxicity of certain benzene derivatives and related compounds 
Smyth, HF 
1931 
Yes 
Journal of Industrial Hygiene and Toxicology
ISSN: 0095-9030 
13 
3 
87-96 
English 
A brief general discussion of the degree and type of toxic action of benzene derivatives under the groups of homologues of benzene, nitro- and amino-compounds and diamines, is followed by a discussion of the results of acute toxicity tests on laboratory animals of guanidine and certain guanidine derivatives, anilin and some of its derivatives and compounds, diphenyl and certain diphenyl derivatives, nitrobenzene, phenyl-[alpha] and [beta]-naphthylamines, m- and p-tolylendiamine and a group of condensation products. With most of these preparations the toxicity was rather low. There is very little danger of accidental poisoning in industry with any material having a minimum lethal dose of over 0.25 gm. per kgm., or 17.5 gm. for a man weighing 70 kgm. With limits under that point but over 0.1 gm. per kgm., there is little danger in handling the preparations if their possible toxicity is realized and reasonable precautions are taken as to dust and fume removal and personal cleanliness. Personal idiosyncrasy may make exceptions to this rule, and fat soluble or lipid soluble materials, if water insoluble, may poison by skin absorption in doses not toxic by mouth.