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HERO ID
5920866
Reference Type
Journal Article
Title
Intrathoracic retention of insoluble hyaluronic acid and its absorption process in rats
Author(s)
Uemura, A; Ogawa, S; Tanaka, R
Year
2019
Is Peer Reviewed?
Yes
Journal
International Journal of Artificial Organs
ISSN:
0391-3988
EISSN:
1724-6040
Page Numbers
391398819885126
Language
English
PMID
31692411
DOI
10.1177/0391398819885126
Abstract
BACKGROUND:
Post-thoracotomy adhesions are frequent postoperative complications. It has been reported that insoluble hyaluronic acid may prevent adhesions.
MATERIALS AND METHODS:
This study had two objectives: first, to determine the in vivo degradation and absorption process, as well as the intrathoracic retention, of solid insoluble hyaluronic acid membrane; and second, to elucidate the association between postoperative intrathoracic retention and the morphological changes of insoluble hyaluronic acid in 12 Wistar rats. Insoluble hyaluronic acid membranes were cut into 2.0 cm × 1.0 cm rectangles in a dry state. After weighing, the test membranes were soaked and washed with saline to be implanted after pericardiotomy via thoracotomy. At Days 4, 7, 10, 14, and 28 after implantation, the rats were euthanized, the chest was opened, and the condition and implantation site of the inserted test membrane were examined.
RESULTS:
Although approximately 10 days were required for the test membrane to decrease to half in the thoracic cavity, the intrathoracic remnant decreased to a mean of ~2% just 4 days later.
CONCLUSION:
This study clarified the time-dependent degradation process and remnants of insoluble hyaluronic acid in the thoracic cavity. A close relationship between the intrathoracic remnant of insoluble hyaluronic acid and its morphological change associated with degradation was demonstrated.
Tags
PFAS
•
Expanded PFAS SEM (formerly PFAS 430)
Litsearch: September 2019
PubMed
Not prioritized for screening
3-(Perfluoroisopropyl)-(2E)-difluoropropenoic acid
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