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Citation
Tags
HERO ID
5922420
Reference Type
Journal Article
Subtype
Review
Title
Exosomes: Versatile Nano Mediators of Immune Regulation
Author(s)
Li, Q; Wang, H; Peng, H; Huyan, T; Cacalano, NA
Year
2019
Is Peer Reviewed?
Yes
Journal
Cancers
ISSN:
2072-6694
Volume
11
Issue
10
Language
English
PMID
31615107
DOI
10.3390/cancers11101557
Abstract
One of many types of extracellular vesicles (EVs), exosomes are nanovesicle structures that are released by almost all living cells that can perform a wide range of critical biological functions. Exosomes play important roles in both normal and pathological conditions by regulating cell-cell communication in cancer, angiogenesis, cellular differentiation, osteogenesis, and inflammation. Exosomes are stable in vivo and they can regulate biological processes by transferring lipids, proteins, nucleic acids, and even entire signaling pathways through the circulation to cells at distal sites. Recent advances in the identification, production, and purification of exosomes have created opportunities to exploit these structures as novel drug delivery systems, modulators of cell signaling, mediators of antigen presentation, as well as biological targeting agents and diagnostic tools in cancer therapy. This review will examine the functions of immunocyte-derived exosomes and their roles in the immune response under physiological and pathological conditions. The use of immunocyte exosomes in immunotherapy and vaccine development is discussed.
Tags
PFAS
•
Expanded PFAS SEM (formerly PFAS 430)
Litsearch: September 2019
PubMed
Not prioritized for screening
3-(Perfluoroisopropyl)-(2E)-difluoropropenoic acid
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