Health & Environmental Research Online (HERO)


Print Feedback Export to File
5923133 
Journal Article 
Review 
Influenza Virus Neuraminidase Structure and Functions 
Mcauley, JL; Gilbertson, BP; Trifkovic, S; Brown, LE; Mckimm-Breschkin, JL 
2019 
Yes 
Frontiers in Microbiology
ISSN: 1664-302X 
10 
39 
English 
30761095 
With the constant threat of emergence of a novel influenza virus pandemic, there must be continued evaluation of the molecular mechanisms that contribute to virulence. Although the influenza A virus surface glycoprotein neuraminidase (NA) has been studied mainly in the context of its role in viral release from cells, accumulating evidence suggests it plays an important, multifunctional role in virus infection and fitness. This review investigates the various structural features of NA, linking these with functional outcomes in viral replication. The contribution of evolving NA activity to viral attachment, entry and release of virions from infected cells, and maintenance of functional balance with the viral hemagglutinin are also discussed. Greater insight into the role of this important antiviral drug target is warranted.