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Citation
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HERO ID
5924145
Reference Type
Journal Article
Title
Dinitrile formation in the attempted acylation of malonamide and its alkyl derivatives**School of Pharmacy, Duquesne University, Pittsburgh 19, Pa
Author(s)
Liska, KJ; Shroff, AP
Year
1959
Volume
48
Issue
3
Page Numbers
148-149
DOI
10.1002/jps.3030480305
URL
http://www.sciencedirect.com/science/article/pii/S0095955315348915
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Abstract
Attempted acylation of malonamide and mono-alkylmalonamides with acetyl chloride and pyridine indicates that no acylation takes place at room temperature. At elevated temperatures, the predominant reaction is dehydration to the corresponding dinitrile. Only one compound, n-butylmalonamide, gave a significant yield of acylated product, identified as N-acetyl-α-cyanocaproamide.
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