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5931872 
Journal Article 
Manganese-mediated acetylation of alcohols, phenols, thiols, and amines utilizing acetic anhydride 
Jain, I; Sharma, R; Malik, P 
2019 
1 
Synthetic Communications
ISSN: 0039-7911 
49 
21 
2952-2960 
WOS:000484040100001 
Manganese(II) chloride-catalyzed acetylation of alcohols, phenols thiols and amines with acetic anhydride is reported. This method is environment-friendly and economically viable as it involves inexpensive, relatively benign catalyst, mild reaction condition, and simple workup. Acetylation is performed under the solvent-free condition at ambient temperature and acetylated products obtained in good to excellent yields. Primary, secondary heterocyclic amines, and phenols with various functional groups are smoothly acetylated in good yields. This method exhibits exquisite chemoselectivity, the amino group is preferentially acetylated in the presence of a hydroxyl/thiol group. 
Acetylation; acetic anhydride; manganese(II) chloride; solvent-free; chemoselectivity