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HERO ID
5941077
Reference Type
Journal Article
Title
Unique microRNA expression profiles in cervical cancer
Author(s)
Gocze, K; Gombos, K; Juhasz, K; Kovacs, K; Kajtar, B; Benczik, M; Gocze, P; Patczai, B; Arany, I; Ember, I
Year
2013
Is Peer Reviewed?
Yes
Journal
Anticancer Research
ISSN:
0250-7005
EISSN:
1791-7530
Volume
33
Issue
6
Page Numbers
2561-2567
Language
English
PMID
23749909
Abstract
Cervical cancer is the second leading cause of death among female patients with cancer in the world. Our aim was to analyze cervical cancer cases, in the Southwestern Transdanubian Region of Hungary, with regard to human papillomavirus (HPV) genotype and histological and clinical grading. After HPV testing and genotyping, the expressions of eight different pre-microRNAs (miR-21, miR-27a, miR-34a, miR-146a, miR-155, miR-196a, miR-203, miR-221) in formalin-fixed paraffin-embedded (FFPE) primary human cervical cancer samples were evaluated with the help of the LightCycler 480 PCR System (Roche). Statistically significant overexpression of miR-21 (p=0.004), miR-27a (p=0.018), miR-34a (p<0.001), miR-155 (p=0.021), miR-196a (p=0.032), miR-203 (p=0.037) and miR-221 (p=0.017) were observed in squamous cell carcinoma, regardless of HPV status and clinical grading. Significant overexpression of miR-21 (p=0.004), miR-27a (p=0.02), miR-34a (p<0.001), miR-196a (p=0.027) and miR-221 (p=0.031) was characteristic of HPV-positive squamous cell carcinomas in contrast to adenocarcinomas of the same HPV status.
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