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5950831 
Journal Article 
Gill histopathology in zebrafish model following exposure to aquacultural disinfectants 
Gregori, M; Pretti, C; Intorre, L; Braca, G; Abramo, F 
2007 
0 
Bulletin of the European Association of Fish Pathologists
ISSN: 0108-0288 
27 
5 
185-191 
English 
WOS:000251216800003 
The effect of acute exposure of four disinfectants commonly used in aquacultural practice (formalin, potassium permanganate, benzalkonium chloride and malachite green) was studied on the histological structure of adult zebrafish (Danio rerio) gills. Groups of 8 individuals were exposed to a dose of each disinfectant corresponding to the therapeutic dose (TD) and five folds of the therapeutic dose (5xTD). Gills of all exposed zebrafish showed a higher occurrence of histopathological changes. These alterations included a slightly focal proliferation of interlamellar cells with obliteration of interlamellar spaces, mild infiammatory reaction with leucocyte infiltration and lifting of the epithelial layer from gill lamellae. Fish exposed to potassium permanganate showed more severe histopathological changes consisting of necrotic change of lamellar cells, distorsion and apical necrosis of secondary lamellae.