US EPA

5951459 

Journal Article 

Effects of forced walking stress on formalin-induced paw licking in mice 

Sakurada, S; Onodera, K; Katsuyama, S; Yonezawa, A; Arai, K; Hayashi, T; Furuta, S; Sato, T; Kisara, K 

1999 

1 

Methods and Findings in Experimental and Clinical Pharmacology
ISSN: 0379-0355
EISSN: 2013-0155 

21 

7 

467-470 

English 

10544389 

WOS:000082979200003 

This study examined the effects of exposing mice to forced walking stress on formalin-induced paw licking. At each observation period (0.5-6 h) after exposure to forced walking stress, a significant antinociceptive effect (stress-induced analgesia, SIA) was observed only in the second phase (from 10 to 30 min), but not in the first phase (from 0 to 10 min) of formalin-induced paw licking in mice. The present data showed that SIA induced by exposure to forced walking stress was dependent on duration of the stress (0.5-4 h). SIA was dose-dependently antagonized by the NMDA receptor antagonist dizocilipine (0.01-0.04 mg/kg) but not by naloxone (10 mg/kg). Thus, the present results suggest that exposure to forced walking stress could cause SIA which may be involved in the nonopioid system via NMDA receptors. 

stress-induced analgesia; forced walking stress; formalin test; NMDA 

27th Annual Meeting of the Japanese Society of Neuropsychopharmacology 

Kagoshima, Japan 

1997