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5972526 
Book/Book Chapter 
Hormesis: A common phenomenon in the bio-effects of formaldehyde toxicity 
Cao, Y; Lu, ZS; Duan, LJ; Yan, Y; Wang, GX; Yang, X 
2005 
Tsinghua University Press 
Beijing, China 
Indoor air 2005: Proceedings of the 10th International Conference on Indoor Air Quality and Climate, vol. 5 
3827-3830 
English 
WOS:000233831206061 
Hormesis is a dose-response phenomenon, which is characterized by a counterintuitive switchover from low-dose stimulation to high-dose inhibition that is not infrequently encountered in the course of a toxicity assay. In this paper we provided various data, mainly our findings, to show that hormesis is a common phenomenon in the study of formaldehyde toxicity and these findings have great implications affecting study design, animal model, and endpoint selection as well as clinical applications. In the central nervous system, it has been noticed that formaldehyde can do harm to learning and memory abilities. Our findings in mice exposure to I and 3 mg/m(3) formaldehyde testified this. It is interested to notice, however, mice exposure to 0.5 mg/m(3) formaldehyde have better memory ability than control group. It has also been noticed that formaldehyde can induce the damage of supermolecules such as DNA and proteins, because formaldehyde is highly chemically active. 
formaldehyde; hormesis; biphasic; dual effects 
Yang, X; Zhao, B; Zhao, R 
9787894948304 
10th International Conference on Indoor Air Quality and Climate (Indoor Air 2005) 
Beijing, China 
September 4-9, 2005