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5973058 
Journal Article 
Metal free green protocol for the synthesis of bis-spiro piperidine and pyrimidine derivatives 
Patil, A; Salunkhe, R 
2018 
1 
Research on Chemical Intermediates
ISSN: 0922-6168
EISSN: 1568-5675 
44 
5 
3337-3348 
WOS:000429485300025 
Abstract: A highly efficient one-pot three-component synthesis of bis-spiro piperidine and pyrimidine derivatives has been reported by performing the reaction of formaldehyde, aromatic aniline and 1,3-dicarbonyl compounds. This reaction was carried out at room temperature in 2,2,2-trifluoroethanol (TFE) as a recyclable reaction medium under the metal free condition. The strong hydrogen donor ability and acidic property of TFE plays a key role in accelerating the rate of reaction and initiates the reaction smoothly. The advantageous features of this method are a mild reaction condition, no column chromatographic purification, and high yield of products and recyclability of TFE. Graphical Abstract: [Figure not available: see fulltext.]. © 2018, Springer Science+Business Media B.V., part of Springer Nature. 
2,2,2-Trifluoroethanol; Bis-spiro piperidine; 1,3-Diaryl-hexahydropyrimidine; Multicomponent reaction; Green synthesis; Reusability 
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