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597893 
Technical Report 
Chromosome damage induced by styrene, styrene oxide and some analogues 
Norppa, H 
1981 
Institute of Occupational Health 
Haartmaninkatu 
CIS/84/00816 
University of Helsinki 
English 
Academic dissertation, including a review of the literature on the metabolism and genotoxicity of styrene. In vitro (cultures of human peripheral lymphocytes), styrene and styrene 7,8-oxide, the main reactive metabolite of styrene, and some of their analogues produced structural chromosome aberrations and sister chromatid exchanges. Although styrene oxide was apparently mutagenic in human lymphocytes, neither styrene nor styrene oxide produced detectable chromosome damage in the bone marrow of hamsters. Styrene and vinyltoluene did cause chromosome breakage in the bone marrow of mice, as indicated by the micronucleus induction test. The difference between the 2 rodents is probably due to the relatively low activity of epoxide hydrolase in the mouse, which makes the mouse less able to inactivate styrene oxide. 
STYRENE; STYRENE OXIDE; MUTAGENS; CHROMOSOME CHANGES; CYTOTOXIC EFFECTS; IN VITRO EXPERIMENTS; LYMPHOCYTES; METABOLIC PROCESS; LITERATURE SURVEY; SMOKING; THESIS; FINLAND; METHYLSTYRENES; ILO