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598618 
Journal Article 
Brain tumor and role of β-carotene, α- tocopherol, superoxide dismutase and glutathione peroxidase 
Aggarwal, S; Subberwal, M; Kumar, S; Sharma, M 
2006 
Yes 
Journal of Cancer Research and Therapeutics
ISSN: 0973-1482
EISSN: 0974-1127 
2 
1 
24-27 
The erythrocyte levels of the antioxidant enzymes SOD and GPx, and serum levels of antioxidants vitamins β-carotene and β-tocopherol were estimated in various types of brain tumors, and were compared with the levels in controls. Statistically significant (P<.001) diminished levels of β-carotene, β-tocopherol, SOD and GPx, were observed in all the brain tumor patients as compared to controls. Malignant tumor also showed a relative decrease in antioxidant levels as compared to benign tumors. Comparison of histopathological sections of brain tumors also suggested a inverse relationship between antioxidant level and grades of malignancy. Marked decrease in antioxidant levels may have a role in genesis of considerable oxidative stress in brain tumors. Further more, the degree of decline in antioxidant levels may indicate severity of malignancy in brain tumors. [ABSTRACT FROM AUTHOR] Copyright of Journal of Cancer Research & Therapeutics is the property of Medknow Publications Pvt. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts) 
BRAIN -- Tumors; VITAMIN E; SUPEROXIDE dismutase; GLUTATHIONE; ANTIOXIDANTS; β-carotene; a-tocopherol; Brain tumor; Glutathione peroxidase; Superoxidase-dismutase