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60061 
Journal Article 
Induction of skin tumors in the mouse with minute doses of 9,10-dimethyl-1,2-benzanthracene alone or with croton oil 
Klein, M 
1956 
Yes 
Cancer Research
ISSN: 0008-5472
EISSN: 1538-7445 
16 
2 
123-127 
English 
13293651 
Solutions of 0.06-0.00006 per cent 9,10-dimethyl- l,2-benzanthracene were applied to the skin of 11 groups of Swiss Albino mice once, once monthly, or once followed by repeated application of croton oil. An additional group received croton oil alone. Skin tumors arose among all the groups. Tumor incidence and tumor multiplicity decreased a d latent period increased as less carcinogen was applied. The influence of a single dose of carcinogen on latent period is discussed. No appreciable differences in tumor incidence or multiplicity were encountered whether the same or approximately the same total dose of carcinogen was applied once or in divided amounts. However, the latent period was shorter following the single application. Fewer tumors were elicited with repeated monthly applications of 9,10-dimethyl-l,2-benzanthracene than with one such application followed by weekly treatment with croton oil. © 1956, American Association for Cancer Research. All rights reserved.