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6007765 
Journal Article 
Protection against inhalation toxicity of ricin and abrin by immunisation. AU - GRIFFITHS GD 
Allenby, AC; Bailey, SC; Lindsay, CD; Rice, P; Scawin, JW; Upshall, DG 
1995 
Yes 
Human & Experimental Toxicology
ISSN: 0960-3271
EISSN: 1477-0903 
14 
2 
155-164 
BIOSIS COPYRIGHT: BIOL ABS. 1 Abrin and ricin are highly toxic plant proteins which are very similar in structure and function and inhibit protein synthesis in eukaryotes. 2 Rats have been immunised against either toxin using formaldehyde-toxoids by three subcutaneous injections at intervals of 3 weeks. For abrin, serum titres in 14 out of 15 rats were raised to between 1:12800 and 1:51200 after two injections, 6 weeks from the start of the experiment. Titres of between 1:256 and 1:1024 were also measured in lung washes after challenge with active abrin toxin. 3 The three major antibody classes, IgG, IgM and IgA were present in the immune sera but IgG and IgA only were detected in lung washes. The proportion of IgA to IgG was higher in the lung fluid than in sera. Rats immunised by abrin toxoid were protected against 5 LCt50's of abrin by inhalation but others exposed to ricin were not. 4 For ricin, serum titres ranged from 1:800 to 1:25600 after two injections and after a third injection the titr MH - BIOCHEMISTRY 
AMINO ACIDS; PEPTIDES; PROTEINS; CARBOHYDRATES; THERAPEUTICS; AMINO ACIDS/METABOLISM; PEPTIDES/METABOLISM; PROTEINS/METABOLISM; RESPIRATORY TRACT DISEASES/PHYSIOPATHOLOGY; HYPERSENSITIVITY/DRUG THERAPY; IMMUNITY/DRUG EFFECTS; POISONING; ANIMALS, LABORATORY; MURIDAE; Biochemical Studies-General; Biochemical Studies-Proteins; Biochemical Studies-Carbohydrates; Pathology; Metabolism-Proteins; Respiratory System-Pathology; Pharmacology-Immunological Processes and Allergy; Toxicology-General; Plant Physiology; Plantae-Unspecified; 9009-86-3; 1393-62-0