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6014001 
Journal Article 
The use of mechanistic data in the risk assessments of ten chemicals an introduction to the chemical-specific reviews 
Williams, GM; Whysner, J ; Ames, B ; Boyle, P ; Doull, J; Greim, H; Hayashi, Y ; Hill, RN ; Kimbrough, RD ; Krewski, D; Kroes, R; Monson, R ; Munro, IC ; Rajewsky, MF ; Scheuplein, RJ ; Sugimura, T ; Swenberg, JA ; Travis, CC; Sieber, S 
1996 
1 
Pharmacology and Therapeutics
ISSN: 0163-7258
EISSN: 1879-016X 
71 
1-2 
1-5 
English 
8910946 
WOS:A1996VH86700002 
The International Expert Panel on Carcinogen Risk Assessment of the American Health Foundation has planned, directed and reviewed in depth analyses of mechanistic data for 10 rodent carcinogens. The purpose of this review was to illustrate the use of mechanistic data in carcinogen risk assessment. The mechanisms by which a chemical produces cancer in rodents provided important information for determining whether or not humans would be at risk at low exposure levels. For epigenetic (non-DNA-reactive) carcinogens, current exposure levels for these chemicals below a threshold do not pose a risk. For DNA-reactive agents at sufficient exposures, humans would be expected to be at risk. However, protective mechanisms may lower the expected risk, especially at low-level exposures.