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6019801 
Journal Article 
Effects of formaldehyde, DMSO, benzoyl peroxide, and sodium lauryl sulfate on isolated perfused porcine skin 
Monteiro-Riviere, NA; Rogers, RA; Spoo, JW 
1992 
Yes 
In Vitro Toxicology
ISSN: 0888-319X 
5 
4 
251-260 
Isolated tissue models that are similar to human skin and that have impaired cellular immune systems would be ideal for identifying the early biochemical alterations induced by irritants. The isolated perfused porcine skin flap (IPPSF) is an ideal model for studying these parameters since it has an intact and viable epidermis that is structurally similar to human skin, a functional microcirculatory system, and an isolated immune system. Four cutaneous irritants, dimethylsulfoxide (DMSO), formaldehyde (FM), benzoyl peroxide in DMSO (BP/DMSO), and sodium lauryl sulfate in DMSO (SLS/DMSO), were topically applied to the flap and the physiologic and biochemical profiles of vascular resistance and glucose utilization of the flap monitored over an 8 hr period. Statistically significant changes in vascular resistance was not observed in any of the dosed flaps or C flaps. Decreased glucose utilization was observed in flaps treated with FM, while BP/DMSO treated flaps had marked increases in glucose utilization compared to controls. 
formaldehyde; dimethyl sulfoxide; benzoyl peroxide; sodium lauryl sulfate; Toxicology Abstracts; toxicity; in vitro; X 24151:Acute exposure