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6021931 
Journal Article 
Synthesis, antioxidant, anti-inflammatory anti-microbial activity of 2-[(5-substituted aryl-1'N-substituted aryl amino methyl) pyrazol-3-yl] benzofuran 
Kavimani, S; Kumar, R; Raju, MB; Suganthi, C; Suthakaran, R; Venkappayya, P 
2008 
1 
1 
39-45 
2-[(5-substituted aryl-1 'N-substituted aryl amino methyl) pyrazol-3-yl] benzofuran (4 sub(a-l)) have been synthesized by treating 2-acetyl benzofuran (1) with different aromatic aldehyde in the presence of a strong base to give 2-substituted arylidene acetyl benzofuran (2 sub(a-c)) which on condensation with hydrazine hydrate in ethanol and glacial acetic acid yielded corresponding 2-(5-substituted aryl-4,5-dihydro pyrazolyl) benzofuran (3 sub(a-c))followed by its reaction with aromatic amine and formaldehyde in glacial acetic acid. The structures of the synthesized compound have been established on the basis of IR, super(1)H-NMR and MASS spectra data Compounds have been screened for anti-inflammatpty, antioxidant and antibacterial studies. Among 12 compounds 4b, 4d, 4e, 4g, 4h, 4j, and 4l have shown good antioxidant activity, which were comparable with that of standard drug ascorbic acid. Among 7 compounds screened for anti-inflammatory activity, compounds 4b, 4d, 4h and 4l showed 81.02%, 84.89%, 85.89% and 82.02% inhibition of oedema volume, while the standard drug (Ibuprofen) showed inhibition of 91.15%. Among 12 compounds that were screened against three gram +ve (S.aureus, B.pumilus and B.subtilis) and two gram -ve (E.coli and P.aeruginosa) organisms, compounds 4c, 4e and 4f have shown good activity as antibacterial antifungal agents comparable with that of standard drugs Amipicillin and Griseofulvin respectively. 
Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Drug abuse; Ascorbic acid; Antiinflammatory agents; Ethanol; Antifungal agents; Data processing; Inflammation; Griseofulvin; Aldehydes; Condensation; Formaldehyde; Antioxidants; Aromatics; Benzofuran; Ibuprofen; Hydrazine; Acetic acid; A 01340:Antibiotics & Antimicrobials; K 03340:Effects of Physical & Chemical Factors; J 02340:Antibiotics & Antimicrobials