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6023649 
Journal Article 
The Effect of Oral and Parenteral Immunization With Killed Vaccines on the Fecal Shedding of Mice Fed Yersinia enterocolitica 
Hashimoto, N; Kaneko, KI; Uchida, I 
1982 
44 
3 
539-542 
In the present study, a small number of mice showed serum agglutinin titers of as low as 1:20 after oral inoculation of viable cells; these were apparently not the results of the oral inoculations of killed cells. It was demonstrated that even high agglutinin titers of 1:160 or 1:320 developed by subcutaneous injection of the killed cells could not protect against fecal excretion of the intragastrically challenged organism. These facts indicate that the inhibition of the challenged organism from colonizing in mice is not due to serum antibody. Because the fecal excretion of the challenged viable cells was inhibited by drinking not only the formalin-killed cells but also the heat-killed cells H antigen was not considered to be the responsible factor of the inhibition. Since Lawtone et al. reported that both of V and W antigens are not stable after heating at 80 degree C for 30 minutes, the V and W antigens seemed to be not responsible for the inhibition in spite of a possibility of the used strain's producing these antigens. It was, however, suggested that heat stable substances of the organism might be related to the inhibition. 
clearance; effects on; association; Immunology Abstracts; Microbiology Abstracts B: Bacteriology; Yersinia enterocolitica; antibody response; vaccination; J 02834:Vaccination and immunization; F 06807:Active immunization