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6035076 
Journal Article 
Induction of protective immune response by vaccination against Pseudomonas pneumonia of mink 
Abaas, S; Bergman, R; Elsheikh, LE; Karlsson, KA 
1988 
35 
4 
256-263 
Protection of mink against experimental Pseudomonas hemorrhagic pneumonia was examined after a single vaccination dose with formaline killed bacteria. Humoral immune response to sonicated antigen (SA) or purified lipopolysaccharide (LPS) of P. aeruginosa were assessed by ELISA (Enzyme Linked Immunosorbent Assay) and PHA (Passive Hemagglutination). Although ELISA was more sensitive and reproducible when SA was used, the PHA test proved equally reliable in measuring LPS antibodies. Significant levels of IgG (Immunoglobulin class G) antibodies were measurable through a whole year period both by ELISA and PHA. IgM antibodies were mainly detectable in the first two weeks after vaccination. Vaccinated mink were resistant to challenge infection by a lethal dose of 10 super(9) cfu of the challenge strain. The vaccine induces a serotype specific immunity with IgG antibody as a predominant component. 
vaccination; Immunology Abstracts; Microbiology Abstracts B: Bacteriology; Mustela; pneumonia; immune response (humoral); Pseudomonas aeruginosa; J 02834:Vaccination and immunization; F 06807:Active immunization