US EPA

6037610 

Journal Article 

Antinociceptive and anti-inflammatory activities and acute toxicity of Achillea nobilis subsp. neilreichii extract in mice rats 

Apaydin, S; Baykan, S; Karabay-Yavasoglu, NU; Karamenderes, C 

2007 

1 

Pharmaceutical Biology
ISSN: 1388-0209 

45, no. 2 

162-168 

The ethanol extract of Achillea nobilis L. subsp. neilreichii (Kerner) Formanék (Asteraceae) flower heads was investigated for its antinociceptive and anti-inflammatory activities and for acute toxicity in mice and rats. While the extract exhibited an antinociceptive effect during the late phase of the formalin test (100, 200, and 400 mg/kg, i.p.) and an anti-inflammatory effect in the paw edema test (100 and 200 mg/kg, i.p.), it did not exert any significant antinociceptive effect in the tail-flick test. Furthermore, administration of 400 mg/kg extract increased the latency to hot-plate test at 60 and 90 min. No significant change was detected in sensory motor performance. The acute LC50 value of the extract was 4456 mg/kg (i.p.) in mice. The current results demonstrate that an ethanol extract of A. nobilis L. subsp. neilreichii exerts anti-inflammatory activity. 

Achillea; medicinal plants; flowers; chemical constituents of plants; plant extracts; medicinal properties; bioassays; inflammation; anti-inflammatory agents; analgesic effect; cytotoxicity; Turkey (country); Achillea nobilis subsp. neilreichii