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604891 
Journal Article 
A Green, Guided-Inquiry Based Electrophilic Aromatic Substitution for the Organic Chemistry Laboratory 
Eby, E; Deal, ST 
2008 
Yes 
Journal of Chemical Education
ISSN: 0021-9584 
85 
10 
1426-1428 
The article focuses on electrophilic aromatic substitution (EAS) laboratory that can reduce the hazardous wastes generated in organic chemistry laboratories. EAS laboratory aims to secure the safety of the students and reduce the costs associated with wastes disposal, and it carries out a multistep procedure using aniline, acetic anhydride, and mixture of nitric and sulfuric acids to produce p-nitroaniline. An analgesic called Salicylamide is used as starting material for EAS because the directing effects of the substituents on the aromatic ring complements each other. The iodination of salicylamide is successfully adapted to generate iodine electrophile. Other details of EAS laboratory is also discussed. 
NITROAROMATIC compounds; CHEMICAL processes; SUBSTITUTION reactions; ANALGESICS; NITROANILINE; NITRIC acid; SULFURIC acid; ELECTROPHILES