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610974 
Journal Article 
Female Infertility and Assisted Reproduction: Impact of Oxidative Stress 
Krajcir, N; Chowdary, H; Gupta, S; Agarwal, A 
2008 
Yes 
Current Women's Health Reviews
ISSN: 1573-4048 
4 
1 
9-15 
Oxidative stress (OS) occurs with an overabundance of reactive oxygen species (ROS) generation and the inability of scavengers, i.e. antioxidants, to neutralize excessive loads of ROS. OS has a role in the etiopathologenesis of many factors causing natural infertility. Infertility is a problem of great magnitude affecting 6 million American women. The etiologies of unexplained infertility and recurrent pregnancy loss remain unclear and present a scientific challenge. Oxidative stress may be a piece in this puzzle. Although investigation of the exact mechanisms by which OS causes pathological processes affecting female fertility is ongoing, research has clearly shown that the redox state affects gametes, their interactions, and the resultant embryo. OS has adverse effects on assisted fertility including IVF/ICSI and in-vitro maturation. This article addresses the role of OS in female infertility, the effect it has on assisted reproductive techniques, and OS prevention strategies including the use of in-vivo and in-vitro antioxidant supplementation. [ABSTRACT FROM AUTHOR] Copyright of Current Women's Health Reviews is the property of Bentham Science Publishers Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts) 
INFERTILITY, Female; REPRODUCTIVE technology; OXIDATIVE stress; GENERATIVE organs, Female -- Diseases; BIOTECHNOLOGY; OXIDATION-reduction reaction; DNA damage; in vitro fertilization; ROS scavengers; Spermatozoa; superoxide dismutase