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6115622 
Journal Article 
Determination of Toxic Trace Residues in Penicillins 
Gstrein, K; Nachtmann, F 
1981 
1 
Microchimica Acta
ISSN: 0026-3672
EISSN: 1436-5073 
2 
1-2 
83-92 
The chromatographic determination of residues of N,N-dimethylaniline and formaldehyde in penicillins is described. N,N-Dimethylaniline can be extracted from alkaline solutions into n-hepatane in one step and determined by HPLC (ultraviolet detector) or by gas chromatorgraphy (FID or N-P FID) without further treatment. HPLC and GC with N-P FID proved to be equivalent. The detection limit is in the sub mu g/g range, and the time for the chromatographic separation is only a few min. Formaldehyde can be detected by chromatography only as a derivative at trace levels. Formaldoxime, produced by reaction with hydroxylammonium chloride is determined by GC (N-P FID) at the mu g/g level. 
residues; penicillins; formalin; N,N-dimethylaniline; Toxicology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; detection; chromatography; A 01076:Penicillins; X 24240:Miscellaneous