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6117230 
Journal Article 
Mild N-Alkylation of Amines with Alcohols Catalyzed by the Acetate Ru(OAc)(2)(CO)(DiPPF) Complex 
Figliolia, R; Baldino, S; Nedden, HG; Zanotti-Gerosa, A; Baratta, W 
2017 
Yes 
Chemistry: A European Journal
ISSN: 0947-6539
EISSN: 1521-3765 
23 
58 
14416-14419 
English 
28857344 
WOS:000413167100004 
The acetate complex Ru(OAc)2 (DiPPF) (2) obtained from Ru(OAc)2 (PPh3 )2  (1) and 1,1'-bis(diisopropylphosphino)ferrocene (DiPPF) reacts cleanly with formaldehyde affording Ru(OAc)2 (CO)(DiPPF) (3) in high yield. The monocarbonyl complex 3 (0.4-2 mol %) efficiently catalyzes the N-alkylation of primary and secondary alkyl and aromatic amines using primary alcohols ROH (R=Et, nPr, nBu, PhCH2 ) under mild reaction conditions (30-100 °C) with an alcohol/amine molar ratio of 10-100. Formation of the monohydride RuH(OAc)(CO)(DiPPF) (4) has been observed by reaction of 3 with iPrOH in the presence of NEt3 at RT through an equilibrium reaction. 
alcohols; amines; borrowing hydrogen; N-alkylation; ruthenium